To analyze potential biomarkers for prediction of a PA/AA-ratio  ≥ 0.80 in patients with severe AS before TAVR, AUROC-curves regarding plasma level concentration of BNP, cTnI, sST2, GDF-15, H-FABP, IGF-BP2 and suPAR were figured out. The gene discussed is NPPB; the disease is aortic valve stenosis.