HIPK2 and amyotrophic lateral sclerosis: The potential involvement of HIPK2 in the pathogenesis of ALS has initially been hypothesized by Lee and co-authors, who showed that Hipk2 can link ER stress to cell death via the IRE1a-ASK1-JNK pathway in murine embryonic fibroblasts (MEFs), cortical neurons, and spinal cord motor neurons [62].