The emergent role of the amygdala, here, is supported by our own work in shape diffeomorphometry (Miller et al., 2015a, Miller et al., 2015b) as well as recent studies in MRI (Wang et al., 2021), tau PET (Berron et al., 2021), and tau pathology (Yushkevich et al., 2021) that have seen similarly high levels of atrophy or tau pathology in the amygdala, particularly in early AD. The gene discussed is MAPT; the disease is Alzheimer disease.