As tau has exhibited stronger predisposition over Aβ for segregating to particular brain regions (ERC, Cornu Ammonis 1 (CA1), subiculum) and layers (superficial) of cortex in AD (Braak and Braak, 1991), we use machine-learning based methods to detect neurofibrillary tangles (NFTs) from histological images. Here, MAPT is linked to Alzheimer disease.