CD8A and neoplasm: In order to be effective, epigenetic therapy is expected to exert several of the following functions: 1) to recover/induce tumor neo-antigens presentation [10]; 2) to favor recruitment of antigen–specific cytotoxic CD8+ T cells into the tumor microenvironment (TME) [11, 12]; 3) to restore activating co-stimulatory molecular pathways [13] counteracting T-cell exhaustion [14, 15]; 4) to reduce tumor infiltration by immune regulatory T-cells [16, 17] and myeloid derived suppressor cells (MDSC) [18, 19].