Guadecitabine/ICBs significantly expanded the frequencies of T and NK cells producing IFN-γ in both spleens and tumor-draining lymph nodes, effect associated with an increased frequency of CD107a+ T (Cytotoxic T lymphocytes, CTLs) and NK cells in the spleen, as compared to control and ICBs (Fig. 5 and Supplementary Fig. 3). The gene discussed is LAMP1; the disease is neoplasm.