However, the limitation of this study is that it does not explain how SETD8 combines with the promoter region of RRAD to regulate the transcription of RRAD. We speculate that SETD8 may inhibit the transcription of RRAD by binding a transcription factor to the promoter of RRAD. GPx4 is a key gene in the regulation of ferroptosis and we did not further investigate the relationship between RRAD and GPx4. At the same time, the role of SETD8-RRAD-ferrodeath axis in pancreatic cancer was not further verified in animal experiments. Here, KMT5A is linked to pancreatic neoplasm.