In the comparison between the PM/OVA and PM groups, OVA affected both the immediate and late reaction of asthma by upregulation of the interleukin-4 (IL-4), FcεRI, eotaxin, and MBP in asthma pathway, and cytokine-cytokine receptor interaction pathway (Fig. 6A, C, respectively). The gene discussed is MBP; the disease is asthma.