As a result, DNMT3A expression in ND patients with B-ALL, ranged from 0.0006594 to 1.713 with a median of 0.4363, was significantly higher than that in control patients (range: 0.08055 to 0.1865, median: 0.1147; P = 0.0004, Fig. 2a). The gene discussed is DNMT3A; the disease is acute lymphoblastic leukemia.