MAPK8 and rheumatoid arthritis: In this study, a total of three Necroptosis-related key genes (FAS, MAPK8 and TNFSF10) were obtained by three machine learning algorithms (LASSON, SVM-REF and RF) with the screening condition of gene importance greater than 0.9, etc. The AUC values represented by the area under the ROC curve of these three key genes in the training set were all greater than 0.85, and the AUC values in the validation set were all greater than 0.8, which can indicate that the key genes have certain accuracy and specificity for differentiating RA samples from healthy control samples.