TNF and melanoma: Most secreted factors (TNFα, GM-CSF, G-CSF, PDGF-BB, CCL5, CCL11, IL-3, IL-6) were not induced by exogenous IFNγ in our panel of melanoma cells (Fig. 2F, Supplementary Data S4), confirming the complex inflammatory signaling profile of de-differentiated PD1 PROGs with intrinsic IFNγ signaling.