Although the numbers are small, we noted that PD1 PROG cells with intrinsic IFNγ activity were derived from tumor biopsies with a trend toward lower CD45+ cell content (3/5 tumor dissociates with <10% CD45+ cells) and high macrophage content (2/5 dissociates with >35% macrophages) (Fig. 3A). The gene discussed is PDCD1; the disease is neoplasm.