PTEN and melanoma: Specifically, in the 19 PD1 PROGs with an identified resistance effector, MHC, de-differentiation and PTEN loss show a tendency toward mutual exclusivity in our panel of PD1 PROG melanomas (odds ratio for the co-occurrence of de-differentiation and MHC loss, 0.06; odds ratio for the co-occurrence of de-differentiation and PTEN loss, 0.1; and odds ratio for the co-occurrence of MHC and PTEN loss, 0.5; Table 1).