Moreover, DYRK2 knockdown also makes HT-29 cells, a colorectal cancer cell line that harbor a wild-type FBXW7 allele, more resistant to Paclitaxel-induced cell death whereas SW837 cells, which harbor a somatic deletion of FBXW7 (L403fs) were largely resistant to Paclitaxel regardless of DYRK2 depletion (SFig. 4F). The gene discussed is DYRK2; the disease is colorectal cancer.