After the onset of liver regeneration, acute liver steatosis (peaks at 12–24 h post-surgery) sends signals through lipids-induced acute stress, resulting in activated EIF2S1 pathway (at 24 h post-surgery), and consequently decreased translation of the Mier1 mRNA (at 24 h post-surgery), leading to reduced MIER1 level (around 24–36 h post-surgery); reduced MIER1 in turn increased cell cycle gene expression and cell proliferating (peaks at 40–48 h post-surgery) (Fig. 7k). The gene discussed is MIER1; the disease is fatty liver disease.