TNF and breast cancer: In detail, the only PC-RCT used a GnRH agonist as active comparator [11], two studies assessed the impact of physical exercise on immune factors [19, 23], one ex vivo in vitro study analyzed the impact of bacterial protein (lipopolysaccharide from salmonella minnesota) stimulation at different concentrations on subjects’ blood[17], and the only in vitro study used TD47 breast cancer cells treated with different substances (P, RU486, ZK98734, IL-1beta, TNFa) [20].