ATRX is recurrently mutated in IDH-mutant astrocytoma [14], H3 K27-altered diffuse midline glioma [22], H3 G34-mutant diffuse hemispheric glioma [12] and high-grade astrocytoma with piloid features (HGAP) [20]. Here, ATRX is linked to astrocytoma (excluding glioblastoma).