The use of controllable, reversible motor driven jet injections offers the ability to both produce the jet to break the skin and vacuum to collect the blood sample.14 Jet injection has been used to deliver a range of pharmacological agents, from vaccines to therapeutics.15 Jet delivery of insulin is well accepted by people with diabetes as an alternative to needle injection.16 In future, a jet-injection device may be able to perform both glucose measurement and insulin delivery as an all-in-one device. This evidence concerns the gene INS and diabetes mellitus.