We also studied CAD and non‐CAD patients and examined their serum ANXA2 levels; we found that ANXA2 was markedly higher in CAD patients than in non‐CAD patients, presenting that the development of CAD may be closely correlated with ANXA2 levels, and ANXA2 may be a new predictor. The gene discussed is ANXA2; the disease is coronary artery disorder.