Meanwhile, the high expression of FZD6 indicated poor prognosis not only in GBM but also in gliomas and LGG of TCGA, CGGA, CGGA301, GSE108474 and GSE16011 datasets (except GSE108474-GBM dataset) (Fig. 7E, S6D-H). This evidence concerns the gene FZD6 and central nervous system cancer.