As shown in Fig. S2, the baseline expression level of two out of three miRNAs of the signature (miR-26a-1-3p and miR-487b-3p) is downregulated in the IDH-wt compared to the IDH-mut cells (intracellular fraction), while all the miRNAs of the signature are released at lower levels in the conditioned medium (extracellular fraction) of the IDH-wt glioma cell line compared to the IDH-mut cells. Here, IDH2 is linked to central nervous system cancer.