In particular, we have identified as novel direct targets of the miRNA signature, SH3PXD2B, SH3PDX2A and EFHD2 genes, which encode for signalling-mediating proteins involved in cell adhesion and migration by controlling the invadopodium activity [13, 14], that may contribute to the IDH-wild type (IDH-wt) glioma invasiveness and provide potential targets for combined therapeutic interventions. This evidence concerns the gene IDH2 and central nervous system cancer.