Lastly, it has been demonstrated that TKS4 and 5 may have a partially overlapping function in invadopodia regulation [53] thus their simultaneous inhibition induced by the identified miRNA-signature could counteract possible rescue mechanisms put in place by tumour cells and synergistically strengthen the inhibition of glioma invasive phenotype elicited by the signature. Here, SH3PXD2B is linked to glioma.