SH3PXD2B and central nervous system cancer: Lastly, it has been demonstrated that TKS4 and 5 may have a partially overlapping function in invadopodia regulation [53] thus their simultaneous inhibition induced by the identified miRNA-signature could counteract possible rescue mechanisms put in place by tumour cells and synergistically strengthen the inhibition of glioma invasive phenotype elicited by the signature.