In the BM of shITGB4 tumor-bearing WT mice, we found decreased levels of CD11b+ Gr-1+ cells stemming from the Gr-1Hi SCCInt fraction (see population A in Additional file 6: Fig. S6C) whereas the percentage of Gr-1Hi SCCLo cells (see population B in Additional file 6: Fig. S6C) was increased in both shITGB4 tumor-bearing WT and E-/P-selectin KO mice (Fig. 8D). This evidence concerns the gene ITGAM and neoplasm.