ITGB4 and neoplasm: Based on our observation that ITGB4 KD significantly alters the local and systemic immune environment during initial tumor formation depending on the E-/P-selectin status of the host, we next investigated whether a cooperatively delayed tumor formation can also be observed after combined depletion of ITGB4 and E-/P-selectin in a syngeneic tumor model using fully immunocompetent hosts.