To our surprise, ITGB4 KD alone already notably delayed s.c. xenograft tumor formation: while the time span from tumor engraftment to endpoint was nearly similar in the shControl/WT and shControl/KO groups (36.6 ± 4.1 days vs. 35.3 ± 3.4 days), the shITGB4/WT group showed a significant tumor growth delay (59.3 ± 5.2 days). The gene discussed is ITGB4; the disease is neoplasm.