Integrative Kaplan–Meier analysis suggested that 30 H4M regulators, including ORC1 (Additional file 4: Fig. S4B) and FANCD2 (Additional file 4: Fig. S4C), were significantly associated with the overall survival of HCC patients, whereas only KDM4B was protective (Additional file 14: Table S9). Here, FANCD2 is linked to hepatocellular carcinoma.