METTL3 and small cell lung carcinoma: In this study, we observed that differential expression of METTL3 expression influenced the IC50 of CDDP and VP16 treatment in SCLC cells, and regulating METTL3 expression alone cannot completely reverse the IC50 of chemically resistant cells to the same level as that of chemically sensitive parent cells, which may be related to the unclear mechanism of SCLC chemotherapy resistance and the complex process of SCLC biological behaviour regulated by multiple factors.