The direct activation of central CB1 receptors with exogenous applied synthetic CB1-receptor agonists (e.g. HU210, WIN55, 212-2), by indirect activation of central CB1-receptor with selective FAAH inhibitors (e.g. URB597) or inhibitors of the membrane anandamid-transporter-receptor (e.g. AM404) showed in animal models of depression (e.g. forced swim test, tail suspension test) a significant antidepressive effect [20, 56, 25]. This evidence concerns the gene FAAH and depressive disorder.