We found that n-3 PUFA ameliorated metabolic status of PCOS women, reducing FPG, FINS, HOMA-IR, QUICKI, Adiponectin, TG, TC and LDL-C, but didn’t modulate HDL-C, VLDL-C and hs-CRP levels. The gene discussed is CRP; the disease is polycystic ovary syndrome.