This meta-analysis indicated that n-3 PUFA could ameliorated metabolic status of women with PCOS, by reducing FPG, FINS, HOMA-IR, QUICKI, Adiponectin, TG, TC and LDL-C levels, but couldn’t affect HDL-C, VLDL-C and hs-CRP levels. The gene discussed is ADIPOQ; the disease is polycystic ovary syndrome.