Except tumor cells, macrophages treated by hypoxia also secrete IL-1\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upbeta$$\end{document}β that enhances angiogenesis by VEGF [167]. Here, VEGFA is linked to neoplasm.