Inflammasome components can be expressed and activated by various stimulators in cancer cells [119, 195, 199], fibroblasts [117], and macrophages [196, 200] resulting in the secretion of IL-1β and IL-18, which further modulates the expression of PD-L1 in tumor cells and recruitment of immune-suppressive cells in TME. Here, IL18 is linked to neoplasm.