CD11b+ Gr-1int myeloid cells from Nlrp3−/− mice produce higher levels of C–C motif chemokine ligand 5 (CCL5) and C-X-C motif chemokine ligand 9 (CXCL9) that are responsible for elevated recruitment and activation of NK cells in tumor microenvironment resulting in  a lower number of lung metastasis [132]. This evidence concerns the gene ITGAM and neoplasm.