To investigate the effect of kaempferol on the growth of both ER subtypes of EC cells in vivo, female BALB/c nude mice were inoculated with ER-positive subtype AN3 CA and ER-negative subtype HEC-1-A cells to evaluate the effect of kaempferol on tumor growth in xenograft mouse models, using DDP as a positive control. Here, ESR1 is linked to neoplasm.