For instance, the expansion of IgG+ plasma cells with reduced diversity and maturation [57], as well as increased activated Th17 cells but decreased CD8+ T cells, γδ T cells and Treg cells [58] were detected in inflamed IBD mucosa, which might exacerbate inflammation; additionally, the myeloid cell populations such as altered immature macrophages were accumulated in the inflamed colon of IBD patients, where these cells produced excessive inflammatory cytokines and aggravated epithelial damage [22]. The gene discussed is CD8A; the disease is inflammatory bowel disease.