In view of the fact that the interaction between RBPs and circRNAs may alter the stability of circRNAs or RBPs, we next detected the stability of circCCAR1 in EIF4A3 depletion HCC cells and EIF4A3 mRNA or protein levels in circCCAR1 overexpression or depletion HCC cells. This evidence concerns the gene EIF4A3 and hepatocellular carcinoma.