In additions, WTAP or IGF2BP3 knockdown inhibited the growth, migration and invasion of HCC cells (Fig. S5), while circCCAR1 overexpression reversed these effects induced by WTAP or IGF2BP3 knockdown, indicating that WTAP-m6A-IGF2BP3 axis induced the upregulation of circCCAR1 was related to the growth, migration and invasion of HCC. This evidence concerns the gene IGF2BP3 and hepatocellular carcinoma.