Besides, RIP assay indicated that the enrichment of endogenous circCCAR1 and miR-127-5p pulled-down from Ago2-expressed HCCLM3 and SK-hep-1 cells was markedly elevated in Ago2 pellet as compared with the input control (Fig. S6K). Furthermore, the results of functional experiments showed that miR-127-5p mimics inhibited the growth, migration and invasion of HCC cells (Fig. S6L-N). The gene discussed is AGO2; the disease is hepatocellular carcinoma.