Investigating possible associations between SOX2 and the FOSL genes, we observed SOX2 regulatory activity on FOSL2, and the latter could in turn regulate IL6 gene expression, indicating that IL6 is downstream of FOLS2, which itself is a target of SOX2. Pathway analysis on SOX2 ChIP-seq data revealed activation of pathways driving the development of several cancers as well as pro-inflammatory pathways. The gene discussed is SOX2; the disease is cancer.