The anti-inflammatory function of GLP1-RAs was suggested to be through the inhibition of tumor necrosis factor alpha (TNFα) and decreases in vascular cell adhesion protein 1 (VCAM-1), intercellular adhesion molecules 1 (ICAM-1) and E-selectin expression in an animal sepsis model [43]. The gene discussed is ICAM1; the disease is Sepsis.