CD70 and acute myeloid leukemia: In addition, we analyzed the expression level of CD70 mRNA based on data from the Cancer Genome Atlas Program and the Genotype-Tissue Expression project using an online tool GEPIA [30], and found that the level of CD70 mRNA in AML blasts (n = 173) was comparable to corresponding normal tissues (n = 70), but CD70 mRNA expression level in diffused large B-cell lymphoma (n = 47) was significantly increased compared with normal controls (n = 337) (Supplementary Fig. 3), consistent with the membrane expression level of CD70 protein identified in this study.