Due to the prominent role in maintaining physiological neuronal excitability, pathogenic variants in KCNQ2 account for a wide spectrum of early-onset human epileptic disorders, ranging from self-limited familial neonatal epilepsy (SeLFNE; OMIM: 121200) to developmental and epileptic encephalopathy (DEE7, KCNQ2-DEE; OMIM: 613720) [6–9]. This evidence concerns the gene KCNQ2 and developmental and epileptic encephalopathy.