With respect to implications for the RAGE pathway in DIAPH1-dependent regulation of F-actin polymerization, it is important to note that previous studies linked S100A8/A9 (ligands of RAGE) to phosphorylation of Cofilin in MDA-MB-231 breast cancers through RAGE, as revealed in experiments with silencing of AGER42. The gene discussed is DIAPH1; the disease is breast cancer.