SREBF2 and atherosclerosis: In summary, our findings unveil new roles for the formin DIAPH1 in the regulation of cholesterol and triglyceride metabolism in a manner independent of direct transcriptional regulation of Srebf1, Srebf2, and Mxlipl. This work presents a new lens into DIAPH1 functions in the regulation of hepatic lipid metabolism, actin organization, nuclear translocation of SREBP1 and their collective impact on atherosclerosis.