To date, tumor-derived secreted cytokines, such as vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF), stromal cell-derived factor 1, and transforming growth factor-β (TGF-β), which form premetastatic niches, induce the mobilization of bone marrow-derived cells. The gene discussed is TGFB1; the disease is neoplasm.