PSPH and acute lymphoblastic leukemia: Moreover, PSPH knockdown in three RPL10 R98S negative T-ALL cell lines impaired leukaemic cell proliferation and reduced in vivo expansion potential of the T-ALL cells in patient-derived xenograft (PDX) mouse models, demonstrating that also RPL10 R98S negative T-ALL samples depend on high PSPH expression levels for their expansion capacity [12].