We found that the ten candidate ICD genes (CALR, ENTPD1, FOXP3, HSP90AA1, IFNB1, IFNG, IL6, LY96, PIK3CA, and TLR4) may affect the prognosis of ccRCC, but their mechanisms of action have yet to be studied in vitro and in vivo, and we are also working on related basic experiments to investigate the mechanisms and possible biological functions. Here, TLR4 is linked to nonpapillary renal cell carcinoma.