LGALS9 and colorectal neoplasm: In the present study, we showed that galectin-9 expression levels in colonic polyps and non-polyp tissues were similar between WT and Clec7a−/− mice (Supplementary Fig. 3m), suggesting that β-glucans in food rather than the endogenous ligand is involved in the Dectin-1-dependent regulation of colorectal tumor development.