TOP2A and neoplasm: By scRNA-seq analysis, we found a group of DCs, which we named tumor-associated DC (TADC) because this DC subset uniquely expresses tumor-associated genes such as Pclaf, Spc24 and Top2a (Supplementary Fig. 3d), highly expressed Il22ra2 in Clec7a−/− mice but not in WT mice (Fig. 6m).