Dectin-1 signaling is reported to aggravates airway hypersensitivity by inducing proallergic chemokines and mucus8, and administration of a Dectin-1 agonistic ligand curdlan evokes arthritis, spondyloarthritis and ileitis in an autoimmune-prone mouse with a spontaneous mutation in ZAP-709,10. This evidence concerns the gene CLEC7A and Arthritis.