To investigate the potential role of Dectin-1 in intestinal tumorigenesis, we first examined the influence of Clec7a gene deficiency (Clec7a−/−) on the development of colorectal tumor in DSS-treated ApcMin (ApcMin-DSS) mice, in which intestinal adenoma is induced due to enhanced β-catenin activity26. Here, CLEC7A is linked to colorectal neoplasm.