We further showed that both CD11c–CD11b+Ly6Cint and CD11c–CD11b+Ly6Chi population were reduced in the polyps of ApcMin/+Clec7a−/− mice (Supplementary Fig. 2d), suggesting that Dectin-1 signaling facilitates MDSC expansion in intestinal tumors. The gene discussed is ITGAX; the disease is intestinal neoplasm.