By examining the TCGA database, we found that the survival rate of CRC patients with high expression levels of CLEC7A and PTGES was lower than that of low expression group, and that of patients with high expression of IL22RA2 was higher, although the relationship between CLEC7A expression and survival rate was not statistically significant (Supplementary Fig. 6g). The gene discussed is IL22RA2; the disease is colorectal carcinoma.