NOS2 and colorectal carcinoma: To confirm these results, we analyzed another scRNA-seq dataset of CRC patients from GEO (GSE146771), and found that the transcription levels of VEGFA were also in parallel with S100A9, PTGS2 and CLEC7A in pseudotime-trajectory (Supplementary Fig. 7j), although the expression of neither ARG1 nor NOS2 was detectable (in MDSCs or in any other leukocytes).