SRC and colonic neoplasm: With the discovery of SRC as the first human proto-oncogene6, and the recognition that somatic GOF mutations in SRC promote colon cancer and liver metastasis7, and that germline GOF SRC mutations cause thrombocytopenia, myelofibrosis, and non-inflammatory bone pathologies8, an oncogenic potential of other Src family kinase members has been of concern.