A2M and focal segmental glomerulosclerosis: A recent study also found that the transcriptional level of glomerular alpha-2-macroglobulin (A2M) was related to lower proteinuria remission rates, connecting long-term outcomes and endothelial function in FSGS.137 Single-cell RNA transcriptomics from urine samples of FSGS patients was also used to investigate disease-related molecular signatures.