KL and renal fibrosis: HDAC4 inhibition by MC1568 also decreased the level of profibrotic factors and preserved Klotho, BMP-7, and Smad7 expression.188 Tubastatin A and ACY-1215 as HDAC6 inhibitors presented antifibrotic effects in different CKD models.215,216 Quisinostat alleviated renal fibrosis in UUO and Ang II-induced hypertension by inhibiting HDAC11 and subsequently repressing KLF15.217