HDAC8 and Balkan nephropathy: RGFP966 as an HDAC3-selective inhibitor could improve kidney fibrotic damage in both aristolochic acid nephropathy and UUO mice.214 PCI34051, a highly selective inhibitor of HDAC8, decreased the number of tubular epithelial cell G2/M-phase arrest as well as suppressed UUO surgery-induced Smad3, STAT3, β-catenin phosphorylation and Snail expression.188,200 Furthermore, inhibition of HDAC8 restored the reduction of Klotho and BMP-7 in UUO experimental model.