Christoph et al. totally profiled 87362 kidney cortex cells from 13 patients of CKD owing to hypertensive nephrosclerosis.18 After defining myofibroblasts that express a large proportion of ECM genes, they reported three main myofibroblast sources in kidneys: PDGFRα+PDGFRβ+MEG3+ fibroblast; PDGFRβ+COLEC11+CXCL12+ fibroblast; and PDGFRα–PDGFRβ+RGS5+NOTCH3+ pericytes. Here, PDGFRB is linked to chronic kidney disease.