SOX9 and acute kidney injury: SOX9 as a transcription factor is responsible for cell growth and differentiation in multiple organs including kidneys.77 Kang et al. have found that SOX9-positive cells of kidneys showed progenitor-like functionalities, and contributed to the regeneration of epitheliums after injury.78 Some studies have consistently explored that the loss of SOX9 function underlined a failure of survived PT cells to repair after AKI.79–81 However, SOX9 is also crucial for kidney fibrosis.