Some well-established pairs of ligand-receptor in the crosstalk of glomerular cells were identified such as endothelial Flt1-podocyte Vegfa.122 The recent study of early-stage diabetic nephropathy patients by single-nucleus RNA transcriptomics showed no significant difference (P = 0.66) in the number of podocytes because of the limited sample number.125 The expression podocyte PLA2R1 and THSD7A in early-stage diabetic patients were increased in comparison to a previous study of later-stage diabetes whose PLA2R1 was greatly reduced. This evidence concerns the gene PLA2R1 and diabetic kidney disease.