The renin-angiotensin system (RAS) blockade,8,240,241 SGLT2 inhibitor,242,243 GLP-1 receptor agonist,244,245 Atrasentan (endothelin-1 blocker),246 Tolvaptan (vasopressin receptor 2 antagonist)247 and Finerenone (non-steroidal anti-mineralocorticoid)248 can delay the progression of CKD (especially in DKD) to varying degrees. The gene discussed is SLC5A2; the disease is chronic kidney disease.