DNER and renal fibrosis: BET proteins as epigenetic readers contain Brd2-4, and Brdt.218 Increasing studies report that BET proteins could modulate kinds of cell functions such as pericyte/fibroblast activation, inflammation, cell growth, and differentiation.218,219 Using JQ1, I-BET151, and ZLD2218 to inhibit BET protein could prevent the inflammatory response, inhibit G2/M-phase cell arrest, and suppress profibrotic signaling activation, contributing to the delay of renal fibrosis.220–223