MCIDAS and ciliopathy: This domain is required for the transcriptional activity of both GEMC1 and MCIDAS, and mutations in the TIRT domain of MCIDAS have been implicated in the rare ciliopathy Reduced Generation of Multiple Motile Cilia (RGMC) that is characterized by the loss or dysfunction of motile cilia on MCCs, causing hydrocephaly, defects in respiratory physiology and infertility [14, 15].