In colorectal cancer, loss of p53 function plays a critical role in colorectal tumourigenesis, and p53 is also crucial for chemotherapeutic drug response, and loss of p53 abolishes the apoptotic response to 5‐flurorouracil (5‐FU) in CRC cells [18, 19, 20]. Here, TP53 is linked to colorectal carcinoma.