ASCL1 and glioblastoma: In particular, ASCL1 has been shown to recognize its neuronal targets in a closed chromatin state when overexpressed in fibroblasts (initiating neuronal reprogramming), undifferentiated neural stem cells, and glioblastoma stem cells (Wapinski et al. 2013; Raposo et al. 2015; Park et al. 2017).