Our recent studies in cultured human hepatocytes and mouse models have revealed that STK25 deficiency protects against liver steatosis by shifting the metabolic balance from lipid anabolism towards lipid catabolism.7–9,11,14,15 This raises the possibility that TAOK1/TAOK3 and STK25 function in the same signaling pathway and that interaction with STK25 may play a part in the molecular mechanism of action of TAOK1/TAOK3 in the regulation of hepatocellular lipotoxic milieu. The gene discussed is TAOK3; the disease is Hepatic steatosis.