NOTCH1 and Hepatic fibrosis: CD44 and TLR4 regulate type I and IV collagens and TIMP1; TLR4 regulates type III collagen; and CD44 regulates type VI collagen.4 TLR4 is a crucial receptor for LPS and translocated intestine-derived LPS promotes HSC activation and liver fibrosis.54 Similarly, HA-mediated TLR4 activation contributes to liver fibrosis progression.4 In HSCs, CD44 contributes to Notch1 activation.