MTOR and progeroid syndrome: Given that mTOR inhibitors, namely rapamycin (Cao et al., 2011) and everolimus (DuBose et al., 2018), have shown some promise in vitro in treating progeria cells and genetic reduction of mTOR in LmnaG608G/G608G progeria mice extended lifespan ~30% (Cabral et al., 2021), we also sought to examine functional effects of lonafarnib + rapamycin versus lonafarnib and rapamycin alone.