LMNA and Hutchinson-Gilford progeria syndrome: Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare condition that results from a de novo autosomal dominant mutation to the gene (LMNA) that codes the nuclear envelope scaffolding protein lamin A (De Sandre-Giovannoli et al., 2003; Eriksson et al., 2003), which results in intranuclear accumulation of an aberrant form of the protein called progerin.