HNRNPA2B1 and amyotrophic lateral sclerosis: Highlighting, the importance of hnRNPs and splicing activity, mutations in the low complexity domains of hnRNP A2B1 and hnRNP A1 have been found casual for ALS [44], with mutations in hnRNP A2B1 producing widespread splicing changes in fibroblasts and motor neurons [45].