We have previously found that hnRNP L can regulate the splicing of the TDP-43 target, SORT1 [17], silencing of hnRNP L in Drosophila neurons, alone or in combination with TDP-43 fly ortholog, led to severe locomotor defects, signaling a genetic interaction of these 2 proteins that illicit ALS linked phenotypes [40]. Here, TARDBP is linked to amyotrophic lateral sclerosis.