To determine if hnRNP L can bind and regulate UNC13A cryptic RNA splicing in a physiological relevant cell type, we performed CLIP of hnRNP L-bound RNAs in human neuroblastoma (M17) cells in which TDP-43 has been down-regulated using siRNA targeting TARDBP (siTARDBP, Fig 6B). The gene discussed is UNC13A; the disease is neuroblastoma.