ALDH3A2 and metabolic disease: Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) is the key gene caused Sjogren-Larsson Syndrome (SLS) which is a rare congenital metabolic disorder that can lead to severe skin and neurological disorders, such as ichthyosis (scaly, thickening and dry skin), neurological disorders and retinal diseases.