Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) is the key gene caused Sjogren-Larsson Syndrome (SLS) which is a rare congenital metabolic disorder that can lead to severe skin and neurological disorders, such as ichthyosis (scaly, thickening and dry skin), neurological disorders and retinal diseases. This evidence concerns the gene ALDH3A2 and ichthyosis.