Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) is the key gene caused Sjogren-Larsson Syndrome (SLS) which is a rare congenital metabolic disorder that can lead to severe skin and neurological disorders, such as ichthyosis (scaly, thickening and dry skin), neurological disorders and retinal diseases. The gene discussed is ALDH3A2; the disease is Other metabolic disease.