CRP and rheumatoid arthritis: Other directions to explore the mechanisms that increase HSA stability are: (1) Using more specific surface modifications or chemical crosslinking reagents to carry out in-depth surface probing of HSA, collect specific information about HSA binding partners and coordination changes [93, 94], and (2) comparing HSA and CRP protein binding partners in RA and non-RA patients using immunoaffinity purification together with mass spectrometry to understand how a change in CRP concentration could be contributing to HSA interactor changes.