Furthermore, no bone pathology was recorded among patients with cluster of differentiation 40 ligand (CD40L) deficiency, dedicator of cytokine 8 d (DOCK8) deficiency, immune dysregulation, polyendocrinopathy, enteropathy X-linked (IPEX), or activated PI3K delta syndrome (APDS). Here, DOCK8 is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.