Furthermore, no bone pathology was recorded among patients with cluster of differentiation 40 ligand (CD40L) deficiency, dedicator of cytokine 8 d (DOCK8) deficiency, immune dysregulation, polyendocrinopathy, enteropathy X-linked (IPEX), or activated PI3K delta syndrome (APDS). The gene discussed is CD40LG; the disease is polyendocrinopathy.