Since macrophages from the synovium of patients with active rheumatoid arthritis (GSE10500) [65] exhibit a pro-inflammatory gene profile that resembles that of GM-CSF-dependent pro-inflammatory monocyte-derived macrophages (GM-MØ) [21] (Supplementary Fig. 2A), we next sought to determine whether LXR inhibition affected the acquisition of the pro-inflammatory profile of GM-CSF-dependent macrophages. This evidence concerns the gene CSF2 and rheumatoid arthritis.