On the other hand, and although the influence of LXR on MAFB can be direct or indirect, the presence of functional LXRα-binding elements within the human MAFB gene in HT29 colorectal adenocarcinoma (http://cistrome.org/db/#/, CistromeDB: 69,799) [74] suggests that LXR factors might have a direct effect on the expression of genes directly controlling the inflammatory profile of monocyte-derived macrophages. The gene discussed is NR1H3; the disease is colorectal adenocarcinoma.