MAFB and multicentric carpo-tarsal osteolysis with or without nephropathy: In agreement with the higher expression of MAFB, the gene expression profile of GSK/RASF-MØ was significantly enriched in MAFB-dependent genes (GSE155719) (Fig. 5C, D), as well as genes upregulated in macrophages from a patient with Multicentric Carpo–Tarsal Osteolysis (MCTO, Online Mendelian Inheritance in Man #166300), a very rare autosomal dominant disorder caused by mutations within the MAFB transcriptional activation domain [68, 69] that result in higher MAFB protein levels [23] (Fig. 5E).