In the current study, the diagnosis of clinical endometritis was performed via assessment of the concentration of pro-inflammatory cytokines (IL-1, IL-6, and TNF-α) and APPs (CRP, total proteins, albumin, and globulin) in the serum of cows with clinical endometritis and recorded higher serum concentration of pro-inflammatory cytokines which was associated with clinical endometritis. The gene discussed is CRP; the disease is endometritis.