In to understand the biology and fate of the ηCTF fragment, we expressed it in human neuroblastoma cells (SH-SY5Y) and analyzed its expression by western blot using APP-Cter and the WO2 antibodies targeting, the carboxy terminal end of APP and the amino-terminal part of Aβ peptides, respectively (Fig. 1a). This evidence concerns the gene APP and neuroblastoma.